1. Why does the Cosmetic Anticorrosion Challenge Test Assessment Technical Guide recommend the use of CMCC strains?
The Cosmetic Anticorrosion Challenge Test Assessment Technical Guide recommends CMCC strains as test strains, mainly based on the simplicity of the purchase process and the availability of strains. Although ATCC strains originate from the Global Biological Resource Center, they are expensive and the purchase process is complicated. When users purchase ATCC strains, they need to provide a number of materials including a letter of commitment, application form, unit profile, biosafety certificate, product transfer agreement and business license, and accept supervision and inspection by China Customs. These requirements undoubtedly increase the difficulty for most domestic cosmetics registrants and filers, making it difficult for many cosmetics registrants and filers to obtain them through formal and legal channels. In addition, the long transportation cycle of ATCC strains may bring uncertainty to the test. In contrast, as a domestic standard strain, CMCC strains are relatively cheap and easy to obtain, and their purchase process is relatively simple, saving a lot of time and cost for cosmetics registrants and recorders, and are more suitable for anticorrosion challenge tests.
2. Can cosmetics registrants and filers choose other methods to conduct anti-corrosion challenge test evaluations?
This Technical Guide is a non-mandatory reference document. Its main purpose is to provide guidance and suggestions for cosmetic registrants and recorders when conducting relevant tests. Cosmetic registrants and recorders can choose industry standards, international standards (such as ISO 11930) or self-built methods according to their actual needs and circumstances to comprehensively evaluate the effectiveness of the product's preservative system.
3. If the product uses the four neutralizers listed in Appendix A.6 to A.9, but the verification results show that these neutralizers are still unable to effectively neutralize certain strains, what solutions should be taken?
The four neutralizers in Appendix A.6 to A.9 are only recommended neutralizers. Cosmetic registrants and recorders can choose appropriate neutralizers according to the actual product formula.
4. Can the mixed bacterial inoculation method be added to the Technical Guidelines?
Mixed bacterial inoculation may lead to differences in test results from single bacterial inoculation, increasing the complexity and uncertainty of result evaluation. Considering the consistency and repeatability of test results, and following the recommended practices of international standards, the mixed bacterial inoculation method is not adopted in the Technical Guidelines.
5. What are the evaluation requirements for the anti-corrosion challenge test for products with the same anti-corrosion system and similar formula?
For products with the same anti-corrosion system and similar formula, the effectiveness of the product anti-corrosion system can be evaluated by referring to the existing information and experimental data, and an anti-corrosion challenge evaluation report can be formed, and the explanatory materials of its anti-corrosion system and formula system can be submitted.
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